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"The Sign" is the twelfth episode of the sixth season of Agents of S.H.I.E.L.D..
With time running short, the team will have to go to hell and back to stop the end of everything. Who will survive?
- Clark Gregg as Sarge
- Ming-Na Wen as Melinda May
- Chloe Bennet as Daisy Johnson/Quake
- Iain De Caestecker as Leo Fitz
- Elizabeth Henstridge as Jemma Simmons
- Henry Simmons as Alphonso Mackenzie
- Natalia Cordova-Buckley as Elena "Yo-Yo" Rodriguez
- Jeff Ward as Deke Shaw
- Karolina Wydra as Izel
- Briana Venskus as Agent Piper
- Coy Stewart as Flint / Izel
- Joel Stoffer as Enoch
- Portia Bartley as Kaya
- Teodora Marcella as Lindsay
- Jan Uddin as Isaiah
Continuity and References to the Marvel Cinematic Universe
- Flint Monolith Recreation appears.
- Izel appears.
- Enoch appears.
- Robbie Reyes is mentioned.
- Spirit of Vengeance is mentioned.
- Phil Coulson is mentioned.
- Trevor Khan is mentioned.
- Sequoia is mentioned.
- Snowflake is mentioned.
- Elon Musk is mentioned.
- Destruction of the Shrike Tower is mentioned.
- Battle of Chicago]] is mentioned.
- Escape from the Dystopian Future is mentioned.
- Framework is mentioned.
- Remorath is mentioned.
- Adriel appears on picture.
- Boaz appears on picture.
- Esau appears on picture.
- Silas appears on picture.
- Uriah appears on picture.
- Remorath Rumble is mentioned.
- Atom Bomb is mentioned.
To be added