Typhoid was one of Kirigi's elite warriors, a member of The Hand and a powerful ninja. During the head council of The Hand, one of the clan leaders calls Kirigi's team a "circus of freaks", but Typhoid poisons him with her powers, thus impressing the rest of the council. When Kirigi is assigned with the task to kidnap Abby Miller and kill her father and Elektra Natchios, a rogue ninja from The Chaste who's become their protector, Typhoid follows him to McCabe's safe house, where the trio is hidden. When they arrive, Elektra and the Millers have escaped, leaving McCabe behind, but they are easily tracked down by the ninjas in the nearby forest. Typhoid reaches Elektra and has a brief fight with her, during which she easily defeats the ninja girl with her poisonous kiss. Just before Typhoid and Kirigi flee with Abby, Stick and his ninjas arrive and make The Hand escape with empty hands.
During the second fight between The Hand and Elektra, while Tattoo incapacitates Abby, Typhoid reaches her and, disobeying her master's order, she tries to kill her, since she's jealous, being her the previous Treasure. She manages to kill the girl, but Elektra stabs her with one of her sais immediately after, and then uses the Kimagure arts to resurrect Abby.
Typhoid was a cruel and cold ninja, who uses her appeal to seduce and then kill her opponents. She's voluptous and mortal as a snake. Her powers allow her to emit poisonous gas from her body, especially from the mouth, and she uses a technique called Death Kiss to finish off her enemies by breathing poison directly in their lungs.
- Kirigi - Leader; deceased.
- Roshi - Leader.
- Stone - Teammate; deceased.
- Tattoo - Teammate; deceased.
- Kinkou - Teammate; deceased.
- Elektra Natchios - Enemy.
- Abby Miller - Enemy and rival.
- The Chaste - Enemies.
Behind the scenes
- While she has no comic book counterpart, Typhoid's name is obviously based off the Daredevil villain Typhoid Mary, a villain with a split-personality disorder. Additionally, her powers are different from Typhoid Mary's, because while Typhoid has the power of poison, Typhoid Mary has the power of telekinesis and pyrokinesis (The ability to create fire with her mind).
- Despite her being named after Typhoid Mary, Typhoid is the only other original character in Kirigi's group created for the film besides Kinkou.
- Natassia Malthe and Jennifer Garner were nominated for Best Kiss at the 2005 MTV Movie Awards.